The UK Census provides a wealth of secondary data. Household spaces with no usual residents may suggest dereliction, health, economic activity and employment statistics may all be useful measures.
DataShine is a useful wesite for accessing and visualising census data.
The Consumer Data Research Centre (CDRC) provides access to a range of data sets including IMD, some Census statistics and also a collection of other data sets about Urban places including house prices, travel to work, dwelling age, industry of employment. All of these are useful when investigating quality of life.
The police.uk website allows you to search crime statistics for any area of the UK – either by postcode search, or you can define your own search area.
You can download a spreadsheet of crimes which can be added to GIS by dragging and dropping the spreadsheet onto a map – allowing you to map crime hotspots.